Complications following intramuscular diclofenac
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چکیده
منابع مشابه
Pharmacokinetics of diclofenac in sheep following intravenous and intramuscular administration.
OBJECTIVES The aim of this work was to examine the pharmacokinetics of diclofenac (DCLF) in sheep after intravenous (IV) and intramuscular (IM) dosing. ANIMALS Healthy male Najdi sheep. MATERIALS AND METHODS Diclofenac (1 mg kg(-1)) was administered to ten clinically healthy-male Najdi sheep IV or IM (n = 5 each). Blood samples (5 mL) were collected and serum was separated for drug analysis...
متن کاملUpper limb gangrene following intramuscular diclofenac: a rare side effect
Diclofenac is a very commonly used analgesic medication. Diclofenac is a non-steroidal anti-inflammatory drug and acts by inhibiting COX (cyclo-oxygenase) 1 and 2. It has both analgesic and anti-pyretic effects. It can be administered both orally and parentarelly. Among the many side effects of diclofencac, extensive ganrene of the extremities is never reported as one of the probable complicati...
متن کاملNicolau syndrome following intramuscular diclofenac administration: a case report.
Nicolau syndrome (livedoid dermatitis) is a rare adverse reaction of a still largely unidentified pathogenesis at the site of intramuscular drug injection. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, haemorrhagic patch, and finally necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has been related to ...
متن کاملSkin necrosis after self-administered intramuscular diclofenac.
Intramuscular diclofenac is used extensively for pain relief in medical practice. Tissue necrosis is a rare but serious complication of intramuscular injections. The pathogenetic mechanism is still not completely understood. A case of tissue necrosis following self-administration of diclofenac inadvertently injected into an arterial perforator branch of the superficial femoral artery is reporte...
متن کاملA comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on postoperative pain following laparoscopy.
Sixty patients presenting for in-patient gynaecological laparoscopic surgery were randomly allocated to receive either diclofenac 75 mg (n = 20), ketorolac 30 mg (n = 20) or piroxicam 20 mg (n = 20) as an intra-muscular injection immediately after induction of anaesthesia. Postoperative visual analogue scores over the first 24 hours, using a 10 cm scale, ranged from 3.2-0.5 in the diclofenac gr...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1992
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1992.tb01993.x